Must Reads

• ​There's a reason fallen leaves smell so distinctive this time of year

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• All about an ironic new TikTok trend that's getting young people to put their phones down

Health

"Timing Is Critically Important": Preemptive Treatment May Delay Alzheimer's, Trial Finds

For this week's news on Alzheimer's developments (this was last week's), a recent clinical trial found that an experimental drug may help delay the disease in high-risk individuals — particularly when given before symptoms of cognitive decline appear.
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Researchers administered an antibody called gantenerumab to individuals aged between 30 and 50 who had no symptoms of Alzheimer's, but do have a rare genetic mutation that nearly guarantees they will develop the condition down the road. While gantenerumab has previously been linked to clearing amyloid plaques in the brain, which are associated with Alzheimer's, this is the first research to suggest that taking the drug as a preemptive treatment may help preserve cognitive function for longer.
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"It doesn't stop the dementia. Dementia still continues, but at a slower rate," research lead Dr. Randall Bateman told CBS News, explaining that participants who took the drug are doing 30% better than untreated individuals. "Timing is critically important," he added.
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The study is part of a worldwide network of early-onset Alzheimer's trials that are likely to continue for at least another five years, and the results could mean big things for future research. Bateman said: "If this trial holds up and we can continue to demonstrate benefit year after year that these people are protected, then I actually think that will predict what's gonna happen in the near future in ongoing prevention trials: That they will be positive, they will work, they will give people years of dementia-free life."

Together With RAD Intel

The AI Startup Everyone's Talking About

Every family's got that uncle — the one who "called Nvidia early" and won't let anyone forget it. Well, he's talking about RAD Intel now.
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​RAD Intel's AI platform helps Fortune 1000 brands predict ad performance before they spend — turning wasted budgets into measurable results. Backed by Adobe, Fidelity Ventures, and insiders from Google, Meta, and Amazon, the company has grown valuation 4,900% in four years,* secured recurring seven-figure partnerships across major household brands, and doubled sales contracts in 2025 already.
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Whether you're a skeptic or a seasoned investor, this is one story you'll want in on before the price moves. Shares are just 81 cents until Nov. 20 — invest today.​

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Sports

Meet the Trailblazer Taking on a Record-Breaking, Solo Antarctic Crossing

"FINISH LINE!!! I did it!" Colin O'Brady wrote in 2018 after completing the first solo, unsupported, and unaided crossing of Antarctica, covering 932 miles in 54 days. Now, seven years later, the adventurer is pushing that finish line even farther, embarking imminently on an unprecedented 1,780-mile journey across the continent over 110 days — adding on the Ross and Filchner ice shelves in addition to the Antarctic landmass between them.
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"I'm really curious if I can go back and push myself not just farther in distance … but in a spiritual context — mind, body, soul," he told NBC News. "And to me, there's no better proving ground for that than Antarctica." Should he succeed, O'Brady will have another notch on his trailblazing belt, becoming the first individual to traverse the entire continent on foot, traveling solo and without any external support, from one ice shelf to the other.
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The journey ahead will be anything but easy: He will face temperatures as low as minus 60 degrees Fahrenheit, hauling a 500-pound sled loaded with all his supplies while wearing just a single set of clothes.
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If you think this sounds like the stuff of an adventure documentary, you'd be right. Netflix is following O'Brady for an upcoming doc, offering viewers a front-row look at what's sure to be quite a ride. As O'Brady puts it, it's a reminder to push one's limits despite fear: "I'm definitely afraid of dying. I'm not trying to take some crazy risk or something like that. But when I really put my head on the pillow at night, what I'm more afraid of is not fully living." Learn more about the trek — and how you can track O'Brady in real time.

Science

New, Easy-to-Apply Gel Can Regrow Tooth Enamel, Scientists Say

We mean no disrespect to dentists when we say that many people would be happy if they never had to visit one again. Of course, dental hygiene is critical to overall health (and breath), so even some of us with dentophobia dutifully schedule cleanings and necessary procedures. But what if there were a way to protect and repair our teeth without invasive interventions?
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A research team led by scientists at the U.K.'s University of Nottingham have made headway on that very issue. Publishing their results earlier this month, they created a bio-inspired gel that can regenerate eroded enamel and prevent future decay. It's applied to teeth in the same way dentists apply fluoride gel, but works by mimicking the proteins that guide enamel growth in developing teeth.
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"The technology has been designed with the clinician and patient in mind. It is safe, can be easily and rapidly applied, and it is scalable," study co-author Alvaro Mata said in a news release. "Also, the technology is versatile, which opens the opportunity to be translated into multiple types of products to help patients of all ages suffering from a variety of dental problems associated with loss of enamel and exposed dentine."
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Where can we sign up, right? Mata and his team "hope to have a first product out next year," he said. In the meantime, brush up on the right way to brush your teeth.

In Other News

1. A keyboard for people with Parkinson's disease won this year's James Dyson Award in the medical category (read more)
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2. Scientists captured the first close-up image of the sun's magnetic field near the south pole — check it out (read more)
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3. Forest funds and Indigenous voices are on the agenda at this year's U.N. Climate Change Conference (read more)
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4. This women's soccer team won the Big 10 tournament in honor of their goalkeeper, who died days earlier (read more)
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5. Bootsy, a cat lost during Hurricane Helene, unexpectedly returned home more than a year after going missing (read more)

Inspiring Story

Friends who restore wetlands together, stay together

Some friends get dinner together, others have game nights, but one group of pals in Charleston, South Carolina, formed The MARSH Project to restore a tidal wetland that runs through their neighborhood. They host trash cleanup events, plant native species, and in the process, gain a new sense of hope. "We can be paralyzed by the bad news that we are fed every day, or we can work within our local communities and engage with people and actually do things," said co-founder Joel Caldwell.

Photo of the Day

T minus nine days until Wicked: For Good hits theaters. But in the meantime, there's plenty of "wicked" news circulating to keep us entertained — from a hat worn by Margaret Hamilton ("the Wicked Witch of the West") in 1939's The Wizard of Oz going up for auction to pics from the sequel's European premiere, where stars Cynthia Erivo and Ariana Grande stepped out hand in hand.

Embrace Pet Insurance Helps Soften the Blow of Hefty Vet Bills

Vet bills can be astronomical these days — but Embrace Pet Insurance helps you stay prepared. Get unlimited reimbursement at any vet, plus coverage for accidents, illnesses and more. With over 18 years of expertise, Embrace makes protecting your pet simple. Click below to share a few of your pet's details and get your personalized quote from Money.

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Odds & Ends

🐻 This bear had to take Tahoe's ice-skating rink for a test run
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🤔 Why are people saying "honestly" more often?
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🦻 These are the Rolls-Royces of hearing aids (and they're under $100)*
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🌙 In Boston, you can step into the pages of Goodnight Moon
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​*Indicates a Nice News brand partnership or affiliate

Quote of the Day

"The mystery of life is not a problem to be solved; it is a reality to be experienced."

– J.J. VAN DER LEEUW